{"product_id":"nad","title":"NAD+","description":"\u003cp data-source-line=\"1-1\"\u003e\u003cstrong\u003eNAD+ Complex with Quercetin \u0026amp; Resveratrol\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"3-3\"\u003eA dietary supplement providing 500 mg of NAD+ (nicotinamide adenine dinucleotide) combined with quercetin and resveratrol. This formula is designed to support cellular energy metabolism, mitochondrial function, and overall cellular health through three complementary compounds studied for their roles in aging, metabolism, and cellular resilience.\u003c\/p\u003e\n\u003cp data-source-line=\"5-5\"\u003e\u003cstrong\u003eWhat's In It:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"7-7\"\u003e•\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eNAD+ (Nicotinamide Adenine Dinucleotide) - 500 mg\u003c\/strong\u003e: A critical coenzyme present in every cell that functions as an electron carrier in cellular respiration. NAD+ exists in two forms: NAD+ (oxidized) and NADH (reduced), and this interconversion is fundamental to energy metabolism.\u003c\/p\u003e\n\u003cp data-source-line=\"9-9\"\u003e\u003cstrong\u003eNAD+'s Cellular Roles:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-source-line=\"10-14\"\u003e\n\u003cli data-source-line=\"10-10\"\u003eEssential cofactor for glycolysis, the citric acid cycle, and the electron transport chain—the processes that convert nutrients into ATP (cellular energy)\u003c\/li\u003e\n\u003cli data-source-line=\"11-11\"\u003eSubstrate for sirtuins (SIRT1-7)—proteins that regulate DNA repair, gene expression, inflammation, and metabolic homeostasis\u003c\/li\u003e\n\u003cli data-source-line=\"12-12\"\u003eRequired by PARPs (poly ADP-ribose polymerases)—enzymes involved in DNA repair and genome stability\u003c\/li\u003e\n\u003cli data-source-line=\"13-14\"\u003eSubstrate for CD38 and other NAD+-consuming enzymes involved in cellular signaling\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-source-line=\"15-16\"\u003e\u003cstrong\u003eThe NAD+ Decline Issue:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eResearch demonstrates that NAD+ levels decline with age—by approximately 50% between ages 40-60 in various tissues. This decline is attributed to:\u003c\/p\u003e\n\u003cul data-source-line=\"17-21\"\u003e\n\u003cli data-source-line=\"17-17\"\u003eIncreased consumption by CD38 (which increases with age)\u003c\/li\u003e\n\u003cli data-source-line=\"18-18\"\u003eDecreased synthesis from precursors\u003c\/li\u003e\n\u003cli data-source-line=\"19-19\"\u003eIncreased NAD+ degradation\u003c\/li\u003e\n\u003cli data-source-line=\"20-21\"\u003eReduced mitochondrial function\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-source-line=\"22-22\"\u003eDeclining NAD+ levels correlate with reduced sirtuin activity, impaired mitochondrial function, decreased cellular repair capacity, and various age-related metabolic changes.\u003c\/p\u003e\n\u003cp data-source-line=\"24-25\"\u003e\u003cstrong\u003eOral NAD+ Supplementation:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eA critical consideration: NAD+ is a large, charged molecule (molecular weight 663 g\/mol) that has poor bioavailability when taken orally. It's generally broken down in the digestive tract into component parts (nicotinamide, ribose, adenine). Most longevity researchers focus on NAD+ precursors like NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside) rather than direct NAD+ supplementation, as precursors have demonstrated better absorption and ability to raise cellular NAD+ levels.\u003c\/p\u003e\n\u003cp data-source-line=\"27-27\"\u003eHowever, some research suggests that enteric coating or specific formulation methods may protect NAD+ through digestion, though evidence is still emerging. This product provides direct NAD+ rather than precursors.\u003c\/p\u003e\n\u003cp data-source-line=\"29-29\"\u003e•\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eQuercetin Dihydrate Extract (250 mg)\u003c\/strong\u003e: A flavonoid polyphenol found in onions, apples, berries, and other plants. Quercetin has been studied for:\u003c\/p\u003e\n\u003cul data-source-line=\"30-35\"\u003e\n\u003cli data-source-line=\"30-30\"\u003eAntioxidant properties (directly scavenges free radicals)\u003c\/li\u003e\n\u003cli data-source-line=\"31-31\"\u003eSenolytic potential (may help clear senescent \"zombie\" cells that accumulate with age)\u003c\/li\u003e\n\u003cli data-source-line=\"32-32\"\u003eSupport for healthy inflammatory response pathways\u003c\/li\u003e\n\u003cli data-source-line=\"33-33\"\u003ePotential to inhibit CD38 (the enzyme that degrades NAD+), theoretically helping preserve NAD+ levels\u003c\/li\u003e\n\u003cli data-source-line=\"34-35\"\u003eZinc ionophore properties (facilitates cellular zinc uptake)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-source-line=\"36-36\"\u003eQuercetin has relatively low bioavailability (approximately 2-17% absorption) but its metabolites may contribute to biological effects.\u003c\/p\u003e\n\u003cp data-source-line=\"38-38\"\u003e•\u003cspan\u003e \u003c\/span\u003e\u003cstrong\u003eJapanese Knotweed Extract (150 mg, standardized to 98% Resveratrol)\u003c\/strong\u003e: Provides approximately 147 mg of trans-resveratrol, a polyphenolic stilbene compound also found in grape skins and red wine.\u003c\/p\u003e\n\u003cp data-source-line=\"40-40\"\u003e\u003cstrong\u003eResveratrol's Studied Effects:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-source-line=\"41-46\"\u003e\n\u003cli data-source-line=\"41-41\"\u003eSirtuin activator—particularly SIRT1, which regulates mitochondrial biogenesis, fat metabolism, and cellular stress resistance\u003c\/li\u003e\n\u003cli data-source-line=\"42-42\"\u003eActivates AMPK (AMP-activated protein kinase), a key metabolic sensor that promotes fat oxidation and glucose uptake\u003c\/li\u003e\n\u003cli data-source-line=\"43-43\"\u003eAntioxidant and anti-inflammatory properties\u003c\/li\u003e\n\u003cli data-source-line=\"44-44\"\u003eStudied for cardiovascular support through effects on endothelial function and lipid metabolism\u003c\/li\u003e\n\u003cli data-source-line=\"45-46\"\u003eNeuroprotective properties examined in animal models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-source-line=\"47-48\"\u003e\u003cstrong\u003eBioavailability Challenge:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eResveratrol has poor oral bioavailability (approximately 1% reaches systemic circulation unchanged) due to rapid metabolism in the intestines and liver. However, metabolites may retain biological activity, and some research suggests benefits despite low bioavailability.\u003c\/p\u003e\n\u003cp data-source-line=\"50-50\"\u003e\u003cstrong\u003eWhat It Does:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"52-52\"\u003eThis supplement aims to support cellular energy production and metabolic health through three mechanisms:\u003c\/p\u003e\n\u003col data-source-line=\"54-57\"\u003e\n\u003cli data-source-line=\"54-54\"\u003e\n\u003cstrong\u003eDirect NAD+ provision\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003e(though absorption challenges apply)\u003c\/li\u003e\n\u003cli data-source-line=\"55-55\"\u003e\n\u003cstrong\u003ePotential NAD+ preservation\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003evia quercetin's CD38 inhibition\u003c\/li\u003e\n\u003cli data-source-line=\"56-57\"\u003e\n\u003cstrong\u003eSirtuin activation\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003ethrough resveratrol, which may complement NAD+'s role as a sirtuin substrate\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003cp data-source-line=\"58-58\"\u003eThe combination theoretically addresses cellular energy metabolism, mitochondrial function, DNA repair processes, and cellular stress resistance—all relevant to healthy aging and metabolic function.\u003c\/p\u003e\n\u003cp data-source-line=\"60-60\"\u003e\u003cstrong\u003eRealistic Expectations:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"62-62\"\u003eEffects are subtle and cumulative rather than immediately perceptible. Those interested in NAD+ support for longevity or metabolic optimization may notice improvements in energy levels, recovery, or mental clarity over 4-8 weeks of consistent use, though responses vary significantly between individuals.\u003c\/p\u003e\n\u003cp data-source-line=\"64-65\"\u003e\u003cstrong\u003eImportant Consideration:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eThe longevity and anti-aging research community generally favors NAD+ precursors (NMN, NR) over direct NAD+ due to bioavailability concerns. If desired effects are not achieved with this formula, NAD+ precursor supplements may be worth exploring.\u003c\/p\u003e\n\u003cp data-source-line=\"67-67\"\u003e\u003cstrong\u003eWho Might Use This:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"69-69\"\u003eAdults interested in longevity optimization, cellular health support, metabolic function, individuals experiencing age-related energy decline, biohackers, or those seeking to support healthy aging processes through nutritional supplementation.\u003c\/p\u003e\n\u003cp data-source-line=\"71-71\"\u003e\u003cstrong\u003eSourcing \u0026amp; Production:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"73-73\"\u003eManufactured in the USA.\u003c\/p\u003e\n\u003cp data-source-line=\"75-75\"\u003e\u003cstrong\u003eProduct Specifications:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul data-source-line=\"76-81\"\u003e\n\u003cli data-source-line=\"76-76\"\u003eServings per Container: 30 (60 capsules)\u003c\/li\u003e\n\u003cli data-source-line=\"77-77\"\u003eServing Size: 2 capsules\u003c\/li\u003e\n\u003cli data-source-line=\"78-78\"\u003eNet Weight: 1.8 oz (0.11 lb \/ 50g)\u003c\/li\u003e\n\u003cli data-source-line=\"79-79\"\u003eTotal Weight: 2.4 oz (0.15 lb \/ 68g)\u003c\/li\u003e\n\u003cli data-source-line=\"80-81\"\u003eCountry of Origin: USA\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp data-source-line=\"82-83\"\u003e\u003cstrong\u003eUsage Instructions:\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAdults: Take two (2) capsules daily with 6 oz (177 ml) of water, preferably with food to enhance absorption of quercetin and resveratrol (both fat-soluble compounds benefit from dietary fat). For optimal results, take consistently at the same time each day, or as directed by your healthcare professional.\u003c\/p\u003e\n\u003cp data-source-line=\"85-85\"\u003e\u003cstrong\u003eImportant Safety Information:\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp data-source-line=\"87-87\"\u003eDo not exceed recommended dose. Pregnant or nursing women, children under 18, and individuals with known medical conditions should consult a physician before use. Resveratrol may have mild anticoagulant effects—consult your healthcare provider if taking blood-thinning medications.\u003c\/p\u003e\n\u003cp data-source-line=\"89-89\"\u003eKEEP OUT OF REACH OF CHILDREN. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING. STORE IN A COOL, DRY PLACE.\u003c\/p\u003e\n\u003cp data-source-line=\"91-91\"\u003e*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.\u003c\/p\u003e\n\u003cp\u003e\u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/4c36cdfa54b26cb4291c359dc2cd7910d868f8ae-125x181.png\" alt=\"Gluten-free\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/2390692fa16a1bad9ae4453609bcd8b61afbb0b2-149x180.png\" alt=\"Vegetarian\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/cc4066d915d42e195ee9cf5bbce01a99f006af1e-126x181.png\" alt=\"Lactose-free\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/f7e562d6bb212503da89f944a0d799171e6d48fe-125x181.png\" alt=\"Allergen-free\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/e2132e2f64f15727e375c7aa509fedd7bdcf1ae8-126x182.png\" alt=\"Hormone-free\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/28d7e07bb105f5cdb78b23808a653158de4f4b70-125x182.png\" alt=\"All natural\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/f99540cc3d3f192a68004f4518d57b0cd7c27aa7-125x181.png\" alt=\"Antibiotic-free\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/0e9fc04e2f9353234d2b7794b96613f19c576efb-126x183.png\" alt=\"Non-GMO\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/a007d72855c1d7a309b8b6dec5eadf939bb8a80d-125x181.png\" alt=\"Corn-free\" style=\"height: 6rem; width: auto;\"\u003e \u003cimg src=\"https:\/\/cdn.sanity.io\/images\/g0smbdlu\/production\/392fe7a0ceded284f4aeb9c2eeb40c638917d6be-149x180.png\" alt=\"Vegan friendly\" style=\"height: 6rem; width: auto;\"\u003e\u003c\/p\u003e","brand":"Lang Wellness LLC","offers":[{"title":"Default Title","offer_id":52442836500773,"sku":"JTP4NADP","price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0977\/5104\/0293\/files\/Generated_with_Kive.ai_-_no_people_-_2026-02-28T021329.531.png?v=1779924999","url":"https:\/\/world-safari-shops.myshopify.com\/products\/nad","provider":"World Safari Shops","version":"1.0","type":"link"}